A newly developed synthetic lining that coats the small intestine may have potential to treat conditions, ranging from lactose intolerance to diabetes and obesity, according to investigators from Harvard-affiliated Brigham and Women’s Hospital (BWH) and the Massachusetts Institute of Technology.A team of researchers has been working on an innovative way of sustainably delivering drugs and influencing nutrient absorption in the gut by using the gastrointestinal synthetic epithelial lining (GSEL) system. Because GSEL is designed to coat the small intestine, an organ that plays a key role in drug and nutrient absorption, researchers have demonstrated the GSEL system’s ability to adhere to segments of the gastrointestinal tract from pigs and humans. In pig models, the team has reported potential applications in treating not only diabetes, but tropical diseases such as schistosomiasis.Image showing fresh resected tissue specimens from porcine small intestine without (left) and with (right) ex vivo GSEL coating. Credit: Junwei Li/Science Translational MedicineResults of the team’s proof-of-concept studies are published in Science Translational Medicine.“The small intestine is an amazing organ — it’s the main site of drug and nutrient absorption and digestion and plays an important role as a barrier. We recognized its potential: If we could specifically target this location, it would open up new avenues for drug delivery and nutritional modulation,” said corresponding author C. Giovanni Traverso, a gastroenterologist and biomedical engineer in the Division of Gastroenterology at the Brigham.The GSEL system combines two nature-inspired innovations. The first takes advantage of a chemical reaction triggered by catalase, an enzyme that helps break down hydrogen peroxide into oxygen in the small intestine. The second is a mussel-inspired tissue adhesive, similar to what mollusks use to attach themselves to rocks. Using these two concepts, Traverso, first author Junwei Li, and colleagues designed the synthetic gut lining. Their goal is to develop a capsule, pill or gel that could be ingested, but for now, the team has tested administering the GSEL system endoscopically — that is, directly inserting it into the small intestine.To test the lining’s therapeutic potential, the team looked at pig models for testing lactose intolerance, glucose absorption and the delivery of praziquantel, a drug for treating schistosomiasis. The team found evidence that the lining could deliver the drug in a sustained way, potentially reducing treatment to a once-a-day dose instead of three time a day. It also improved lactose digestion and regulated glucose absorption, indicating its potential for treating Type 2 diabetes and preventing obesity.,In order to move from pig models into human trials, several hurdles remain, including further developing the GSEL system into an ingestible form. For now, Traverso, Li and colleagues are focused on continuing to evaluate safety in preclinical studies.“For our studies, safety is a key focus of our work,” said Traverso. “There are indications that this system can help patients suffering from many diseases, but before we can translate this technology for humans, we need to fully validate its safety and the effects of chronic use.”This work was supported by the Bill and Melinda Gates Foundation grants (OPP1179091), the NIH (EB000244) and funds from the Department of Mechanical Engineering, MIT.Adapted from a Brigham and Women’s news release by Haley Bridger.
RelatedPosts Ighalo: My best moment as ‘Red Devil’ EPL: Crystal Palace stun sloppy Man U EPL: Red Devils attack Palace Michael Owen has thrown his support behind Manchester United’s decision to extend Odion Ighalo’s loan deal and believes the striker has proven his doubters wrong at Old Trafford.Eyebrows were raised when United wrapped up a temporary agreement with Shanghai Greenland Shenhua for Ighalo in January but the 30-year-old seized his opportunity with both hands, racking up four goals and an assist in his opening eight appearances. The break in football caused by the coronavirus crisis put Ighalo’s future in serious doubt as it meant the Nigerian’s contract came to an end with nine Premier League matches remaining of the season.But the Red Devils ended the uncertainty last week as Ighalo, a lifelong fan of the club, put pen to paper on a six-month extension.“I like him, I like him a lot,” former United and England forward Owen said on Premier League Productions.“I know people turn their nose up at him because he’s come from Chinese football or because he’s on loan, he’s not a sexy £60 million player or whatever.“But I tell you what, I like him. “He’s maybe not the full-time No.9 for Manchester United permanently but when you’ve got [Anthony] Martial, when you’ve got Ighalo, when you’ve got [Marcus] Rashford, all of a sudden you’ve got a bit of pace, a bit of pace, a bit of guile.”Asked whether Ighalo could be United’s answer to Divock Origi, Owen replied: “Yeah, but even more of a role I’d say, Ighalo.“I think he’s another level up, to be honest.“I think he would get more game-time for Manchester United than Origi would at Liverpool in the future.“I like him and I think it’s a good move to extend his contract.” Tags: Manchester UnitedMichael OwenOdion Ighalo
Everton midfielder Darron Gibson is likely to require surgery at the end of the season to fix a troublesome thigh problem, according to manager David Moyes. The 25-year-old missed nearly three months from September with the injury and he sat out almost all January and although he has returned to the starting line-up on a regular basis he is still hampered. Gibson scored from long-range in Saturday’s 2-0 win over QPR and Moyes would like to see him do it more frequently but believes it is not possible currently. “After the game on Saturday, I was asked about Darron Gibson’s goal and his shot – I think he could do it more and with more ferocity as well because he’s got a great shot on him,” said the Scot. “He has got a bit of a problem at the top of his thigh which will probably require an operation at the end of the season.” Despite not being 100 per cent Gibson has added a different dimension to Everton’s midfield with his vision and distribution. “What he has given us is that he is good on the ball and he has a better range of passing than maybe some of the other midfielders we have,” added Moyes. “I think overall he has had an impact. He had a bit of a dip midway through after he came back from his injury but his form is good right now.” Press Association
Share Share Catena forecasts ‘record results’ ahead of August interims July 20, 2020 Submit Raketech names Karlsten as new COO May 27, 2020 Catena lauds ‘record’ Q2 as casino drives performance August 19, 2020 Related Articles StumbleUpon Growth has continued for Catena Media, as it continued its aim to become a global leader in quality content with the confirmation of two new acquisitions.The group first announced the acquisition of Forextraders.com, Forexcharts.net and Forexindicators.net, all sites which will be used to create an ecosystem of quality content in the area of foreign exchange as part of the Trade Finance vertical. The acquisitions will provide Catena with the opportunity to improve sites currently focusing on advertising so that they instead focus on lead generation. The acquired assets currently generate quarterly sales of about USD 250,000.Acting CEO Henrik Persson Ekdahl commented on the deal: “Foreign exchange represents major trading volumes, both for professional and non-professional traders requiring reliable information – Catena Media has set-out to become the leader in this space.”ForexTraders.com started in 2004. It is a foreign exchange trading Information site providing details of foreign exchange brokers, sign-up offers and useful information pertaining to the area of foreign exchange. Catena Media will extend this by adding premium content relating to various currencies, newsletters and instructional videos and newscasts. The group followed this up by acquiring the premium Australian stock market news and analysis site, TheBull.com.au together with other key sites, such as TheBull.asia and the domain FatCat.com.au.To build this brand and stay ahead of the competition Catena Media is also acquiring the video-focused sites LearnTrading.com.au and LearnCFDs.com, as well as similar domains, from the author Ashley Jessen, who has published books, articles and several videos on trading. The acquired assets currently generate quarterly sales of about AUD 100,000. TheBull.com.au provides stock market analysis from Australia’s leading finance journalists. Ashley Jessen (author of industry-leading book “CFD’s Made Simple”) will stay with the company and produce a variety of exclusive video content for Catena Media. The sites and IP rights acquired will be used to build an eco-system of quality written, video and audio content. In addition to the sites and domains, the lead-generating business model will be leveraged to improve on current revenue generation. Persson Ekdahl outlined: “Taking a great stock market news publishing site and adding video content, weekly market round-up pod and video-casts, as well as ‘how-to’ videos will be a powerful combination and a first for Australia.”TheBull.com.au was started in 2006 by traders and is run by long-standing finance journalists with no ties to any financial services companies, associations, or any other listed or unlisted companies. It is now based in Melbourne, Australia. TheBull.com.au is a website providing stock news relating to the Australian stock market.The initial purchase price of The Bull, payable in conjunction with the transfer of the assets, amounts to an upfront cash payment of AUD 0.9 million. In addition, there is a deferred payment after six months of AUD 0.25 million based on hand-over obligations being met. The purchase price of LearnTrading.com.au and related assets amounts to a maximum payment of AUD 0.1 million and includes the production of video content for Catena Media sites for one year.
AddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThisALPENA, Mich. — Everyone interested in getting in some ice fishing while you still have time, this weekend is your chance. The Reel Fun ice fishing tournament is this Saturday in Presque Isle Twp.There are more than 1,200 pre–drilled holes ready to be used on Grand Lake. If you’re concerned with this weekend’s unseasonably warm forecast, the host of the event has stated the ice is 15 to 16 inches thick. In order to participate you will need a fishing license and will be required to follow DNR guidelines.If just fishing isn’t enough for you, there are more than $1,500 in prizes on the line that you don’t want to miss out on. Fishing will start at noon. Tickets are $30 and will be available at the gate.Directions to the fishing site are below.From the South: Travel North on Hwy 23 Turn Right on East Grand Lake Road (3.5 Miles) Turn Right and stay on East Grand Lake Road (about 2 miles)Public access is on the left From the North: Travel South on Hwy 23 Turn left on E. Co Road 638 (2.2 miles)Slight right onto Highland Plains Road (1.6miles)Turn left to stay on Highland Pines Road (1.8 miles)Turn Right onto E. Grand Lake Road (3.9 miles)Watch for Public Access Signs – access on the leftAddThis Sharing ButtonsShare to FacebookFacebookShare to TwitterTwitterShare to MoreAddThis Tags: Fish, fishing, Grand Lake, Ice Fishing, Reel FunContinue ReadingPrevious Pigeon River Country State Forest expands by 597 acresNext Art Vision Alpena bringing new sculptures to the Alpena Bi-Path Trail
LOS ANGELES — From 2016 through 2018, Kenley Jansen pitched in 29 of the Dodgers’ 42 postseason games for a total of 39 innings, 14 times in a save situation.This year, he appeared in just two of the Dodgers’ five games against the Washington Nationals in their National League Division Series loss. Neither was in a save situation – he closed out the Dodgers’ 10-4 win in Game 3 and retired two batters after Joe Kelly had given up the decisive grand slam in the 10th inning of Game 5.That usage – and Dave Roberts’ mid-series assertion that he could see using Jansen in non-save situations and not in the ninth inning – reflects the Dodgers’ diminished trust in Jansen two years into an apparent decline in his abilities. That desire to minimize their reliance on Jansen in the highest-leverage situations was certainly a factor in the series of pitching moves that led to disastrous results in Game 5.Jansen has an opt-out clause in his contract this winter that would allow him to leave behind the final two years and $38 million of his deal with the Dodgers and become a free agent. At age 32 and coming off a season that featured his career-highs in blown saves (eight) and ERA (3.71) and his highest WHIP (1.063) since the 2014 season, it would take a thoroughly misguided judgment on the part of Jansen and his representatives to exercise that option. Dodgers’ Max Muncy trying to work his way out of slow start Roberts has described his relationship with Jansen as “good” and “honest.” That relationship could be tested if Roberts has to convince the franchise’s all-time saves leader and one of only six pitchers to record 300 saves with one team that he will no longer be in that role in 2020. But the Dodgers have headed in that direction before.Related Articles How Dodgers pitcher Ross Stripling topped the baseball podcast empire Dodgers hit seven home runs, sweep Colorado Rockies Newsroom GuidelinesNews TipsContact UsReport an Error Cody Bellinger homer gives Dodgers their first walkoff win of season Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco So, does that mean Jansen will be the Dodgers’ closer in 2020?“I’m not sure,” Dodgers president of baseball operations Andrew Friedman said Monday. “I haven’t really gotten into exact specifics of offseason planning, just more broad strokes. My sense sitting here is that Kenley will be our closer. We’ll see how things pan out.”Starting with a spring hamstring injury in 2018 and including his recurrence of atrial fibrillation (leading to surgery a year ago), Jansen and the Dodgers have explained his diminished velocity and less reliable movement of his cut fastball as a result of inconsistent mechanics. Friedman endorsed that theory once again in defending Jansen.“I think it’s one of those things where he feels good and there were decent chunks of time where everything kind of synced up and his stuff was objectively better and other times where he struggled more,” Friedman said. “So much of it is about his delivery and syncing all that back up. Obviously he’s a very large human so sometimes things can get out of whack a little bit. I think the focus this offseason will be about trying to kind of lock that down and having him be able to repeat more consistently.“He’s another guy that as far as making a bet in terms of people doing everything they can to put themselves in the best position to have success, I will absolutely bet on him. When you have that and some awareness we learned during the season when it’s hard to make those adjustments on the fly, I’m excited about what he’s capable of next year and feel like he’ll be a big part of us winning games. What exactly that role will be, I don’t know right now.” In December 2015, the Dodgers had a trade in place to acquire Aroldis Chapman from the Cincinnati Reds but backed out when Chapman was investigated (and eventually suspended) for a domestic-violence incident. This past season, the Dodgers actively pursued a trade for Pittsburgh Pirates closer Felipe Sanchez at the July 31 deadline but would not meet the Pirates’ demands.In both cases, Jansen’s role would have been reduced, at least to sharing the closer role.Like Jansen, Chapman has an opt-out clause he could exercise this offseason and all indications are he will use it to become a free agent. Giants closer Will Smith is also a free agent this offseason. Friedman and the rest of the front office will no doubt identify other potential targets this winter.“I think as far as a jumping-off point to have the returning talent that we have, to have the financial flexibility we have, the depth in house in terms of trade options, I think it gives us a lot of flexibility and I think it’s something where everything is on the table,” Friedman said.“I’m not sure,” Dodgers president of baseball operations Andrew Friedman said Monday when asked if Kenley Jansen, pictured, would be the team’s closer in 2020. “… My sense sitting here is that Kenley will be our closer. We’ll see how things pan out.” (Photo by Harry How/Getty Images)