EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena More Cool Stuff Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy 0 commentsShareShareTweetSharePin it First Heatwave Expected Next Week Your email address will not be published. Required fields are marked * Community News Make a comment faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Darrel Done BusinessVirtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Top of the News Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday Business News Pasadena Tech Company Scores Celebrity Investor, Spokesman From STAFF REPORTS Published on Monday, October 10, 2016 | 7:50 pm Name (required) Mail (required) (not be published) Website Kevin Costner pictured in 2014Pasadena-based Lender Price, an emerging leader in real-time, competitive mortgage analytics and product pricing and eligibility solutions, will have Kevin Costner, Best Picture Oscar winning director and Emmy Award winning actor, appear as its spokesman at the 2016 MBA Annual Convention in Boston on October 23 to 26.Costner is an original investor with Lender Price.“We are of course thrilled that an investor of Mr. Costner’s reputation and vision for innovation has made the decision to vocalize his support for Lender Price at this major mortgage industry event,” said Lender Price co-founder and CEO Dawar Alimi.“We are the first company to apply big data to real-time, competitive mortgage analytics,” said Costner. “When I understood how this would be a game changer, it made me realize that I had to be a part of this. We are transforming the mortgage Fintech space.”The Lender Price MBA Annual Convention exhibit will be at Booth 1431 in Exhibit Hall D and its meeting room will be Beacon G.Lender Price is a California-based big data technology innovator and developer of a real-time, competitive mortgage analytics and product pricing and eligibility (PPE) platform. With Lender Price, wholesale and correspondent lenders, banks, and credit unions can knowledgably manage product pricing for all mortgage types: conforming, non-conforming, non-QM, and specialty loans, delivering innovative features that include built-in compliance checks, capital market tools, margin management, lock desk, customized workflows and mobile functionality.Lender Price allows lenders to focus on what they do best by removing the burden of technology development and management.For more information, visit www.lenderprice.com or send email to: [email protected] Subscribe Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Community News Herbeauty12 Signs He’s Ready To Spend The Rest Of His Life With YouHerbeautyHerbeautyHerbeauty9 Of The Best Family Friendly Dog BreedsHerbeautyHerbeautyHerbeauty6 Fashion Trends You Should Never Try And 6 You’ll LoveHerbeautyHerbeautyHerbeautyBohemian Summer: How To Wear The Boho Trend RightHerbeautyHerbeautyHerbeautyKeep Your Skin Flawless With These Indian Beauty RemediesHerbeautyHerbeautyHerbeautyWhat’s Your Zodiac Flower Sign?HerbeautyHerbeauty Business News
Amyloid-beta protein – the primary constituent of the plaques found in the brains of Alzheimer’s disease patients – may be part of the body’s first-line system to defend against infection.In their report in the open-access journal PLoS One, a team led by Harvard Medical School (HMS) researchers at Massachusetts General Hospital (MGH) describe their evidence that amyloid-beta protein (A-beta) is an antimicrobial peptide. These small proteins are part of the innate immune system, which provides broad defense against a wide range of pathogens.“For years we thought that A-beta was just metabolic garbage produced as a byproduct of other processes within the brain, but these data suggest it is a normal component of the brain’s innate immune system.” says HMS professor Rudolph Tanzi, PhD, director of the Genetics and Aging Unit in the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND), co-senior author of the PLoS One report. “It looks like factors that trigger hyperactivity of the innate immune system – not only infection but also traumatic brain injury and stroke, which are already known to increase the risk for Alzheimer’s – could cause excessive deposition of A-beta.”Shared by all types of plants and animals, the innate immune system is the first line of defense against invading pathogens. The innate system can rapidly mobilize white blood cells, chemical factors called cytokines and antimicrobial peptides to kill bacteria, viruses, fungi and even tumor cells. Antibodies and other components of adaptive immunity have limited access to the brain, but the antimicrobial peptides of the innate immune system play a key role in fighting infection within the central nervous system.A-beta is toxic to neurons, and the protein’s accumulation as plaques in the brains of Alzheimer’s patients is thought to lead to the neurodegeneration characterizing the disorder. The protein is generated when a larger parent molecule called the amyloid precursor protein is cleaved by enzymes. Several different types of A-beta can be generated by the enzyme action; the more common A-beta 40 and A-beta 42 forms are particularly prone to form into toxic plaques. Although A-beta is known to promote inflammation, the protein’s biological activity has been considered purely incidental and only harmful. But the current study suggests that A-beta’s newly discovered antimicrobial activity may play an important role in fighting infection in the brain.After Robert Moir, PhD, of MGH-MIND the Genetics and Aging Research Unit, co-senior author of the PLoS One paper, noticed several physical, chemical and biological similarities between A-beta and antimicrobial peptides – particularly a human protein called LL-37 – he, Tanzi, and colleagues decided to investigate the possible connection. Graduate student Stephanie Soscia tested synthetic versions of both A-beta 40 and A-beta 42, along with LL-37, against a panel of important pathogens and found that A-beta did inhibit the growth of eight of the 15 organisms tested. Against seven of the affected organisms – which included the yeast Candida albicans and forms of the bacteria Listeria, Staphylococcus and Streptococcus – A-beta was as strong or stronger than LL-37. For six of those, A-beta 42 was more potent than A-beta 40.To see if the same antimicrobial activity would be produced by Alzheimer’s-associated A-beta, the investigators tested the ability of brain tissue from Alzheimer’s patients and from age-matched controls to suppress the growth of Candida in culture. Reflecting the fact that amyloid plaques are primarily found in the temporal lobe of the brain, significant antimicrobial activity was observed in samples of temporal lobe tissue from Alzheimer’s patients but not from controls. Not only did the antimicrobial strength of patient samples correlate with the amount of A-beta they contained, the activity was also suppressed by antibodies against A-beta. Another experiment showed that Candida growth was not suppressed by tissue from the cerebellum, an area where A-beta levels are low, from either Alzheimer’s patients or controls.The researchers suggest that chronic activation of the innate immune system in response to either a persistent or transient infection of the central nervous system might lead to excess production and accumulation of A-beta. Known Alzheimer’s risk factors – such as stroke, head injury and exposure to certain anesthetics – could also trigger the innate immune system and increase A-beta production, leading to an excessive and dangerous inflammatory response within the brain.While the rare gene mutations that directly cause inherited Alzheimer’s are known to induce production of high levels of A-beta 42, several novel Alzheimer’s candidate genes recently identified by Tanzi and others play a role in the innate immune system. The investigators are testing the hypothesis that a host of genetic factors may influence risk for Alzheimer’s by mediating the production of A-beta in the brain’s innate immune system.“Now we need to figure out what is triggering the innate immune system, particularly as we age, and what genes control A-beta’s role in the innate response,” says Moir, who is an assistant professor of Neurology at Harvard. “If we can identify which pathogens are more likely to trigger A-beta plaque aggregation, we might develop ways to prevent or control that response, for example by immunization.”The work reported in the PLoS One paper was supported by grants from the Cure Alzheimer’s Fund. “This is the kind of high-risk, high-reward project for which it’s very difficult to get federal funding,” says Tanzi, the Joseph and Rose Kennedy Professor of Neurology at HMS. “We really appreciate their vision in funding this important work.” In addition to lead author Soscia, co-authors of the study are Kevin Washicosky, Stephanie Tucker, and Bradley Hyman, MD, PhD, MGH-MIND; James Kirby, MD, and Scott Duong, Beth Israel Deaconess Medical Center; Martin Ingelsson, Uppsala University, Sweden; and Mark Burton and Lee Goldstein, MD, Boston University Alzheimer’s Disease Center.
The master ensuite looks out over parkland and Moreton Bay. Picture: supplied.“It’s a no-brainer, this is definitely going to set a new record for the area,” he said. “It is real estate gold. Not only is the house sitting on a huge block of land with panoramic bay views and built to commercial standards, it is also a very big, beautiful home.”Mr Sorrentino said in the 17 years he had been selling property in the Wynnum Manly area, this was the first property he had listed on a 4,000sq m plus block. “Properties like this rarely come on to the market,” he said. “The block is nearly ten times the size of what is normally sold in the area and the home is more than double the size of a normal four-bedroom, two bathroom house.”Owners John and Janice Quinn snapped up the property in 1992 for $400,000 when it was an overgrown block with a fibro house. More from newsNoosa’s best beachfront penthouse is about to hit the market12 hours agoNoosa unit prices hit new record high as region booms: REIQ12 hours agoThere is plenty of outdoor entertaining space at 97 Petersen St, Wynnum. Picture: supplied.Spread across two levels, the home was built to a commercial standard with poured concrete slabs and core-filled concrete blocks. There are four bedrooms with walk-in wardrobes and ensuites to each, open-plan living spaces opening to the veranda, a wine cellar and a cabana overlooking to the inground swimming pool. The Quinns recently revamped the property, completely renovating the bathrooms and kitchen and repainting the house. Mr Sorrentino said the property has already drawn interest from potential buyers.“A lot of inquires have been from overseas Asian buyers,” he said.“It surprised me but maybe it shouldn’t because Asian buyers tend to like big homes on big blocks.” WYNNUM’S TOP SALES25 Waterloo Esplande Sale price: $2.5 millionSale date: September 7, 2016 97 Petersen Street, WynnumIs this bayside mansion with ocean views from almost every room, including the master ensuite, a record breaker? Place Manly real estate agent Marc Sorrentino thinks it will be. The 775sq m home, sitting on a 4,037sq m block at 97 Petersen St, Wynnum, has hit the market for the first time since it was built almost 25 years ago. Listed without a price, the property has no street frontage and the only thing sitting between its rear boundary and Moreton Bay is parkland. Mr Sorrentino said the property would smash the Wynnum sales record of $2.5 million. The property at 6 Alverna Close Wynnum. Picture: supplied. The living areas flow out to the verandas. Picture: supplied“At that time, $400,000 was a lot of money. When we bought it everyone said we were paying too much,” Mr Quinn said. “I think the combination of not being able to see the bay because the block was overgrown, plus the fact it was an old purple fibro house meant there was nothing compelling about it unless you saw the vision (of what it could be).” The couple and their two children lived in the three-bedroom shack for a couple of years while working with an architect to design their dream home.Mr Quinn said the resulting 775sq m house took 18 months to build and made the most of the ocean views. “The house was built across the block so just about every room has views of the bay and it had to have large entertaining areas because we like to entertain a lot,” he said. The property at 12 Alverna Close, Wynnum. Picture: supplied.6 Alverna CloseSale price: $2.35 millionSale date: November 29, 2017 The property at 25 Waterloo Esplanade, Wynnum. Picture: supplied.12 Alverna CloseSale price: $2.44 millionSale date: February 26, 2014
“You have the guarantee that after the match, independent of the result, we are together again, enjoying our time and having a laugh. “With David we don’t have this kind of relationship, but we have a good relationship. “I think we can start this kind of very nice relationship I had always with Sir Alex, no problem. “During the game, it’s a game. It’s not manager against manager. It’s club against club, it’s 11 against 11, it’s big players against big players. We just do our job normally.” A potential break in the relationship could be caused by Mourinho’s pursuit of Wayne Rooney. Twice Chelsea have had bids rejected for the Manchester United striker and Mourinho has said a third bid will be made after Monday’s match. Asked how Mourinho will feel if Rooney plays against his side, the self-styled Special One said: “The same emotions I always feel when I play against him. “I played against him with Real Madrid and with Chelsea and with Inter. The emotions is you have to be worried with a good player. No more than that.” Mourinho takes his Chelsea side to Old Trafford on Monday for an opportunity to strike an early blow in the Barclays Premier League title race. The defending champions and the Blues are under new leadership this term, but Mourinho expects the same challenge he faced against Ferguson’s United. Press Association “There are things that we cannot change,” Mourinho said. “David has experience and he knows that he cannot change history. The history that Sir Alex did is there and it is there forever. “Is that a problem for David? I don’t think so. I think David doesn’t want to be compared with Sir Alex. “I think he’s in the best moment of his career – maturity, experience, a big, big, big club, very good players. I think he’s in a fantastic position and I think he’s going to do very well. “I hope he doesn’t win everything and he will leave something for the others, but he’s in fantastic condition.” Mourinho enjoyed a close relationship with Ferguson, who informed the Portuguese of his intention to retire before making the announcement public. After being omnipresent at Old Trafford during Mourinho’s time in management, now there will be a different face in the Old Trafford dugout. “For me the difference is the routine of meeting a friend, of being together and relaxed before the match,” added Mourinho, reflecting on his time in opposition to Ferguson. Jose Mourinho expects David Moyes to thrive as Manchester United manager and does not expect the challenge of succeeding Sir Alex Ferguson to phase the former Everton boss.
Newly elected Executive Committee member of the Ghana Football Association(GFA),Kudjoe Fianoo says he has no interest in the vice president position of the association.The Ashanti Gold CEO Kudjoe Fianoo was on Thursday elected onto the Ghana Football Association’s Executive Committee and now fills the vacancy created by the death of Hon. Emmanuel Owusu Ansah three months ago.The renowned football administrator, picked 10 votes to beat off competition from Asante Kotoko’s Kwame Baah-Nuako, who had 4 votes and J.F. Mensah of Ebusua Dwarfs, who had 2 votes. In all, 16 delegates voted.The vice president position became vacant after the demise of Jordan Anagbla some four months ago. Meanwhile reports are that Chief Executive Officer (CEO)of Hearts Of Oak Fred Crenstil is the candidate proposed for the position
Newcastle legend Shearer: Almiron has no confidence whatsoeverby Paul Vegasa month agoSend to a friendShare the loveToon legend Alan Shearer was unimpressed by Newcastle United’s performance in their 0-0 draw with Brighton.United had chances to win but they had far inferior possession statistics and were indebted to Fabian Schar for keeping out Aaron Mooy’s shot. Even the late introduction of Andy Carroll to attempt to spark the team into life didn’t work. Analysing the match, Shearer said of his former side: “You can see why both of these teams are struggling to score. I thought it was a poor game. Brighton were the better team, Newcastle were really poor.“But still had two very, very good chances they should have scored from. The first one Almiron had no confidence whatsoever. I never fancied him to score. He desperately needs a goal, still hasn’t scored.“And then Joelinton finds himself eight yards out and with a free header (from a corner). He should score.” About the authorPaul VegasShare the loveHave your say
QUEBEC – Quebec’s books are in order and the Liberal government’s budget strategy until the 2020-21 fiscal year is credible, auditor general Guylaine Leclerc said Monday, days before the start of the provincial election campaign.Predictions for future revenues, administrative expenses, salary costs and other budget details are “plausible,” Leclerc told reporters after releasing her report, which was based off her office’s analysis of documents prepared in June by the Finance Department.Leclerc said her review of the province’s books is an “important democratic exercise.”Lawmakers gave the auditor general’s office the mandate in 2015 to evaluate the incumbent government’s finances and budgetary predictions ahead of an election campaign, in order to avoid unpleasant surprises for new political parties that take power.New governments often accused prior administrations of hiding deficits or playing financial trickery, and the Liberals wanted to try to end that by asking the auditor general to review the province’s finances before Quebecers went to the polls.Premier Philippe Couillard said Leclerc’s report demonstrates his Liberal administration is one of the best teams in modern Quebec history with regards to the management of public finances.“We cannot break this momentum,” Couillard said from Scott, Que., in the province’s Beauce region south of Quebec City.Finance Minister Carlos Leitao’s budget documents prepared for Leclerc had predicted Quebec will run an annual budget surplus of roughly $950 million for fiscal 2018-19 through to 2022-23.Revenues from taxes — which represent about 60 per cent of the budget — will increase by 3 per cent in fiscal 2018-19 and maintain the same rate of increase for the next several years.Quebec’s GDP grew by 1.4 per cent in 2016 and 3 per cent the following year. Leitao estimated GDP would increase by 2.1 per cent in 2018 and by 1.7 per cent in 2019.Leclerc said she was not judging the government’s choices but analzying them regarding whether they were realistic.The government also provided sufficient room to manoeuvre in case of unforeseen economic problems, she added.Quebec’s election campaign begins Thursday with the final voting day on Oct. 1.
Another day of big losses knocked U.S. stocks to their lowest levels in more than a year Monday. Investors dumped high-growth technology and retail companies as well as steadier, high-dividend companies. Oil fell below $50 a barrel for the first time since October 2017.On Monday:The S&P 500 index sank 54.01 points, or 2.1 per cent, at 2,545.94.The Dow Jones Industrial Average retreated 507.53 points, or 2.1 per cent, to 23,592.98.The Nasdaq composite tumbled 156.93 points, or 2.3 per cent, to 6,753.73.The Russell 2000 index shed 32.67 points, or 2.3 per cent, to 1,378.14.For the year:The S&P 500 is down 127.67 points, or 4.8 per cent.The Dow is down 1,126.24 points, or 4.6 per cent.The Nasdaq is up 149.66 points, or 2.2 per cent.The Russell 2000 is down 157.37 points, or 10.2 per cent.The Associated Press
VANCOUVER, B.C. – The federal government says it will monitor underwater ship and mammal noise in British Columbia’s Salish Sea to help develop measures to support the recovery of endangered southern resident killer whales.Terry Beech, parliamentary secretary to the transportation minister, announced the measures as his government is set to face new scrutiny on the impacts of the Trans Mountain pipeline expansion on the threatened species.A court ruling found the National Energy Board failed to assess the pipeline project’s effects on the marine environment and the government has asked the board to reconsider that part of the review by Feb. 22. The project would increase tanker traffic in Burrard Inlet seven-fold and whale experts argue there is already too much traffic for the 74-member southern resident whale population to survive.Beech says Transport Canada will spend $1.6 million on measures including deploying an underwater hydrophone, or listening device, at Boundary Pass in the Salish Sea.He also says the department will carry out a four-year project to better predict propeller noise and hull vibration of a vessel.
“If there is no active injection operation nearby then certainly we will consider this to be a natural tectonic earthquake,” Kao said. ROCKY MOUNTAIN HOUSE, A.B. – A second earthquake in less than a week shook central Alberta on Sunday, although a seismologist notes it occurred in a different geologic region than a quake last week that’s been linked to fracking.Honn Kao with the Geological Survey of Canada says the 4.4 magnitude quake was detected at around 4 a.m., with an epicentre about 32 kilometres northwest of Rocky Mountain House.Kao says no damage has been reported, although he says many people who live in the area have reported feeling it, one as far away as Edmonton. A 4.6 magnitude earthquake last Monday that was felt in the communities of Red Deer and Sylvan Lake has prompted the Alberta Energy Regulator to order a company to suspend fracking operations at a well site.Kao notes that while the two quakes were geographically close, Sunday’s quake happened in the Rocky Mountains geological system, whereas last week’s event occurred in the Western Canadian Sedimentary Basin.Cara Tobin, a spokeswoman for the AER, says there doesn’t appear to have been any industrial activity in the area of the most recent earthquake, but staff will be checking the data to make sure.“As inactive as Alberta is tectonically, this area is comparatively active, and so we do see more seismic activity in that area than we do in other areas,” Tobin said of the region where Sunday’s earthquake occurred.In August 2014, a 4.3 magnitude earthquake occurred in the same region. It didn’t do any damage but power was disrupted to about 500 customers, including a gas plant near Rocky Mountain House.Following last week’s quake, the AER said Vesta Energy Ltd. must suspend hydraulic fracturing operations at its well site, and must submit a report of all seismic activity in the area since April, as well as specific fracturing data for the well site from Jan. 29 to March 4. The regulator has also ordered Vesta to file a plan to eliminate or reduce future seismic activity from fracturing.Hydraulic fracturing involves pumping chemicals and sand underground to break up rocks to help get oil and natural gas flowing.Kao said some of the people who felt Sunday’s quake reported they were woken up by the shaking.He said more analysis will be needed to say definitively that the two quakes weren’t linked, but at the moment there doesn’t appear to be any evidence of it.