Appointment Type, Duration: License or Certificate: M.D. or DO, be board certified or eligible in neurology. Work Type: 80% Clinical activities include outpatient clinics, inpatientattending and procedures/10% Participate in extramurally funded clinical research to theextent that the activity can be integrated into clinicalactivities.10% Teach and mentor undergraduates, graduate students, residents,fellows, other attending physicians/providers, and thepublic.The successful candidate will teach medical students, residents,and fellows. The successful applicant will participate inadministrative and committee work to support the clinical andscholarly missions of UW Health and the School of Medicine andPublic Health. An essential part of these duties will be working ina collegial relationship with other faculty members. Wisconsin medical license, M.D. or DO, be board certified oreligible in neurology. Your application must be received through the Jobs at UW portal tobe considered as a candidate. To apply for this position, pleaseclick on the “” button. You will be asked to create a profile andupload a current CV and a Statement of Interest including yourcareer goals and professional plans. At a future date, finalistsmay be asked to provide at least three letters of reference.This vacancy is being announced simultaneously with PositionVacancy Job #97979; please note that only one vacancy exists.Having two position vacancy listings allows the School of Medicineand Public Health to consider clinical teacher faculty candidateswith or without research credentials for this non-tenure-trackposition.The deadline for assuring full consideration is April 19, 2019,however positions will remain open and applications may beconsidered until the position is filled. A535100-MEDICAL SCHOOL/NEUROLOGY/NEUROLOGY Minimum Years and Type of Relevant Work Experience: Department(s): Fellowship training in Headache or equivalent experience. Instructions to Applicants: Employment Class: Job no: 97977-ASWork type: Faculty-Full TimeDepartment: SMPH/NEUROLOGY/NEUROLOGYLocation: MadisonCategories: Health Care, Medical, Social Services, Research,Scientific Diversity is a source of strength, creativity, and innovation forUW-Madison. We value the contributions of each person and respectthe profound ways their identity, culture, background, experience,status, abilities, and opinion enrich the university community. Wecommit ourselves to the pursuit of excellence in teaching,research, outreach, and diversity as inextricably linkedgoals.The University of Wisconsin-Madison fulfills its public mission bycreating a welcoming and inclusive community for people from everybackground – people who as students, faculty, and staff serveWisconsin and the world.For more information on diversity and inclusion on campus, pleasevisit: Diversity andInclusion JULY 01, 2019 Anticipated Begin Date: PROFESSOR (CHS)(D01NN) or ASSOC PROFESSOR (CHS)(D02NN) or ASSTPROFESSOR (CHS)(D03NN) Contact: Additional Information: Ongoing/Renewable Official Title: The Department of Neurology at the University of Wisconsin Schoolof Medicine and Public Health seeks a board certified or boardeligible neurologist with fellowship training in Headache orequivalent experience to join our Headache Program at the UWHospitals, VA Hospital and UW Health clinics. The position includesopportunities for clinical, teaching and research activities in anacademic environment with adult and pediatric neurologists andfaculty in other services including neuropsychology, neurosurgery,neuroradiology, clinical neurophysiology and basic sciencedepartments. Clinical duties include outpatient clinics, inpatientattending and procedures. Candidates must hold an M.D. or DO, beboard certified or eligible in neurology and have or have theability to obtain an Wisconsin medical license.The School of Medicine and Public Health has a deep and profoundcommitment to diversity both as an end in itself but also as avaluable means for eliminating health disparities. As such, westrongly encourage applications from candidates who foster andpromote the values of diversity and inclusion. Applications Open: Mar 18 2019 Central Daylight TimeApplications Close: Kathleen [email protected] Access (WTRS): 7-1-1 (out-of-state: TTY: 800.947.3529, STS:800.833.7637) and above Phone number (See RELAY_SERVICE for furtherinformation. ) Degree and Area of Specialization: Salary: The University of Wisconsin is an Equal Opportunity andAffirmative Action Employer. We promote excellence throughdiversity and encourage all qualified individuals to apply.If you need to request an accommodation because of a disability,you can find information about how to make a request at thefollowing website: https://oed.wisc.edu/disability-accommodation-information-for-applicants/ Full Time: 100% For appointment at Associate or full Professor (CHS) levels, thecandidate must meet criteria as defined in guidelines forappointment or promotion on CHS track in the UW School of Medicineand Public Health. NegotiableANNUAL (12 months) Job Number: Academic Staff-Renewable Principal Duties: 97977-AS Institutional Statement on Diversity: Employment will require a criminal background check. It will alsorequire you and your references to answer questions regardingsexual violence and sexual harassment.The University of Wisconsin System will not reveal the identitiesof applicants who request confidentiality in writing, except thatthe identity of the successful candidate will be released. See Wis.Stat. sec. 19.36(7).The Annual Security and FireSafety Report contains current campus safety and disciplinarypolicies, crime statistics for the previous 3 calendar years, andon-campus student housing fire safety policies and fire statisticsfor the previous 3 calendar years. UW-Madison will provide a papercopy upon request; please contact the University of Wisconsin PoliceDepartment . Position Summary:
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Mathiesons Bakeries has sold a controlling stake in its company to private equity firm Symphony Investment Fund.The Scottish craft bakery got in touch with Symphony to provide some additional fun- ding for the business, which had been struggling during the recession.The deal was confirmed on 3 July and George Stevenson stepped down as managing director on the same day, said Catriona Stevenson, director of sales and marketing at Mathiesons. However, as part of the deal, Mathiesons will be able to buy back the controlling interest in a few years’ time.David Orr previously of United Central Bakeries has replaced George Stevenson as MD, who has assumed the role of non-executive chairman.In an interview with The Falkirk Herald, the former MD, who spent over 30 years in his role, said giving up control of the business was necessary to safe-guard its long-term future.The restructure has resulted in 10 job losses, from its 450-strong workforce.Catriona Stevenson said the company is now running as usual and there are no plans to close any of its shops or restaurants.Mathiesons invested over £4m in a move to a new 47,000sq ft bakery on the outskirts of Falkirk in 2006. The company invested £600,00 in new equipment as part of the move.
Twitter Facebook Pinterest Facebook WhatsApp WhatsApp Crews battle fire in South Bend Friday morning Twitter Pinterest Google+ (Jon Zimney/95.3 MNC) An investigation is underway to determine what caused an early morning fire in South Bend Friday.Firefighters were called to the 2600 block of West Huron Street around 2:30 a.m., where they found a fire emitting from a home that had been converted into apartments.ABC 57 News reports flames and smoke were coming from the home, and the roof also collapsed while firefighters were attempting to put out the blaze.No one was injured. TAGSapartmentsfireIndianaSouth BendWest Huron Street Google+ IndianaLocalNews Previous articleFreeze Warning in effect for listening area early Friday morningNext articleSam Adams Elementary student tests positive for COVID-19 Brooklyne Beatty By Brooklyne Beatty – October 16, 2020 0 502
SNW has now been dissolved by the Commission and ceased to exist when it was removed from the Register of Charities on 15 February 2019.Michelle Russell, Director of Investigations, Monitoring and Enforcement said: An inquiry report published today (21 February 2019) has found that the trustees of Save the Needy Worldwide (SNW) are responsible for a series of failings at their charity amounting to serious misconduct and/or mismanagement. The Commission has removed one trustee and has disqualified another as a result.The inquiry was prompted by proactive engagement by the Commission in 2015 to identify how the trustees of SNW were complying with their legal obligations given the charity was operating in high risk areas internationally. The charity’s objects were the relief of poverty and financial need, in particular for those affected by natural or other disasters overseas.The Commission also identified that one of the charity’s trustees had been a trustee of another charity, Worldwide Ummah Aid (WUA), which is subject to an ongoing statutory inquiry.However, in July 2016, the Commission was informed by Bedfordshire Police that a trustee of the charity had been stopped at Luton airport with £3,260, which was seized by the police under the Proceeds of Crime Act 2002. The Commission obtained further information about the charity’s finances and as a result of concerns opened an inquiry.In order to protect SNW’s funds, the Commission made an order to restrict transactions and payments made by SNW’s trustees. The order prohibited certain cash collections and the withdrawal of charitable funds in cash from the SNW’s bank accounts.The inquiry found that there was misconduct and/or mismanagement by all of the trustees in relation to the administration and management of SNW and that the charity’s property was placed at risk by the trustees who: failed to comply with the Commission’s Action Plan in June 2016; failed to comply with a legal direction to supply information to the Commission; placed the charity’s funds at risk and subsequently lost them as a result of the removed trustee’s conduct; were not sufficiently aware of the activities of the charity (on the part of SNW’s two other trustees) and thereby enabled the removed trustee’s misconduct and/or mismanagement; and could not fully account for the charity’s funds in accordance with charity law. The Commission’s Order under section 79(4) of the Act to remove a trustee, was challenged at the Tribunal; the appeal was dismissed and a copy of the judgement can be found here. The full report of the inquiry is available on GOV.UK.EndsNotes to Editors SNW was a charitable incorporated organisation and was dissolved by the Commission in accordance with the Charitable Incorporated Organisations (Insolvency and Dissolutions) Regulations 2012. Press office The public rightly expects trustees to respect the trust afforded to them as custodians of their charity, as well as the privileged legal status charities enjoy. Our inquiry found that the trustees of Save the Needy Worldwide were responsible for a series of failings at their charity amounting to serious misconduct and mismanagement. It’s therefore right that robust regulatory actions have been taken against those responsible. The charity has also been dissolved as a result of our action. The Commission strongly advises charities against the use of cash couriering as a method to transfer charitable cash due to the risks involved. The effects of a cash seizure include the charities’ beneficiaries losing out, an impact on the charities’ activities and the loss of donor money – including the permanent loss of funds. In this case these risks materialised and there was a loss to the charity. Email [email protected] Press mobile – out of hours only 07785 748787
Take a look our favourite pictures from the big night!The Baking Industry Awards were a evening of recognising talent, but also a night of fun, celebrations and dancing. Created with flickr slideshow.
Amyloid-beta protein – the primary constituent of the plaques found in the brains of Alzheimer’s disease patients – may be part of the body’s first-line system to defend against infection.In their report in the open-access journal PLoS One, a team led by Harvard Medical School (HMS) researchers at Massachusetts General Hospital (MGH) describe their evidence that amyloid-beta protein (A-beta) is an antimicrobial peptide. These small proteins are part of the innate immune system, which provides broad defense against a wide range of pathogens.“For years we thought that A-beta was just metabolic garbage produced as a byproduct of other processes within the brain, but these data suggest it is a normal component of the brain’s innate immune system.” says HMS professor Rudolph Tanzi, PhD, director of the Genetics and Aging Unit in the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND), co-senior author of the PLoS One report. “It looks like factors that trigger hyperactivity of the innate immune system – not only infection but also traumatic brain injury and stroke, which are already known to increase the risk for Alzheimer’s – could cause excessive deposition of A-beta.”Shared by all types of plants and animals, the innate immune system is the first line of defense against invading pathogens. The innate system can rapidly mobilize white blood cells, chemical factors called cytokines and antimicrobial peptides to kill bacteria, viruses, fungi and even tumor cells. Antibodies and other components of adaptive immunity have limited access to the brain, but the antimicrobial peptides of the innate immune system play a key role in fighting infection within the central nervous system.A-beta is toxic to neurons, and the protein’s accumulation as plaques in the brains of Alzheimer’s patients is thought to lead to the neurodegeneration characterizing the disorder. The protein is generated when a larger parent molecule called the amyloid precursor protein is cleaved by enzymes. Several different types of A-beta can be generated by the enzyme action; the more common A-beta 40 and A-beta 42 forms are particularly prone to form into toxic plaques. Although A-beta is known to promote inflammation, the protein’s biological activity has been considered purely incidental and only harmful. But the current study suggests that A-beta’s newly discovered antimicrobial activity may play an important role in fighting infection in the brain.After Robert Moir, PhD, of MGH-MIND the Genetics and Aging Research Unit, co-senior author of the PLoS One paper, noticed several physical, chemical and biological similarities between A-beta and antimicrobial peptides – particularly a human protein called LL-37 – he, Tanzi, and colleagues decided to investigate the possible connection. Graduate student Stephanie Soscia tested synthetic versions of both A-beta 40 and A-beta 42, along with LL-37, against a panel of important pathogens and found that A-beta did inhibit the growth of eight of the 15 organisms tested. Against seven of the affected organisms – which included the yeast Candida albicans and forms of the bacteria Listeria, Staphylococcus and Streptococcus – A-beta was as strong or stronger than LL-37. For six of those, A-beta 42 was more potent than A-beta 40.To see if the same antimicrobial activity would be produced by Alzheimer’s-associated A-beta, the investigators tested the ability of brain tissue from Alzheimer’s patients and from age-matched controls to suppress the growth of Candida in culture. Reflecting the fact that amyloid plaques are primarily found in the temporal lobe of the brain, significant antimicrobial activity was observed in samples of temporal lobe tissue from Alzheimer’s patients but not from controls. Not only did the antimicrobial strength of patient samples correlate with the amount of A-beta they contained, the activity was also suppressed by antibodies against A-beta. Another experiment showed that Candida growth was not suppressed by tissue from the cerebellum, an area where A-beta levels are low, from either Alzheimer’s patients or controls.The researchers suggest that chronic activation of the innate immune system in response to either a persistent or transient infection of the central nervous system might lead to excess production and accumulation of A-beta. Known Alzheimer’s risk factors – such as stroke, head injury and exposure to certain anesthetics – could also trigger the innate immune system and increase A-beta production, leading to an excessive and dangerous inflammatory response within the brain.While the rare gene mutations that directly cause inherited Alzheimer’s are known to induce production of high levels of A-beta 42, several novel Alzheimer’s candidate genes recently identified by Tanzi and others play a role in the innate immune system. The investigators are testing the hypothesis that a host of genetic factors may influence risk for Alzheimer’s by mediating the production of A-beta in the brain’s innate immune system.“Now we need to figure out what is triggering the innate immune system, particularly as we age, and what genes control A-beta’s role in the innate response,” says Moir, who is an assistant professor of Neurology at Harvard. “If we can identify which pathogens are more likely to trigger A-beta plaque aggregation, we might develop ways to prevent or control that response, for example by immunization.”The work reported in the PLoS One paper was supported by grants from the Cure Alzheimer’s Fund. “This is the kind of high-risk, high-reward project for which it’s very difficult to get federal funding,” says Tanzi, the Joseph and Rose Kennedy Professor of Neurology at HMS. “We really appreciate their vision in funding this important work.” In addition to lead author Soscia, co-authors of the study are Kevin Washicosky, Stephanie Tucker, and Bradley Hyman, MD, PhD, MGH-MIND; James Kirby, MD, and Scott Duong, Beth Israel Deaconess Medical Center; Martin Ingelsson, Uppsala University, Sweden; and Mark Burton and Lee Goldstein, MD, Boston University Alzheimer’s Disease Center.
Roll-out Virtual Agent Frameworks – They support the creation of chatbots, which can also be used in a variety of ways across different functions such as HR, customer service and sales.IT Leadership Can Lead the Charge to Transform with Artificial IntelligenceYour company’s IT strategy has a direct impact on its business outcomes. By focusing on the above areas, you can prepare for the inevitable onslaught of AI projects and set your business up to succeed.For additional resources and tips for IT leaders, Forrester Consulting’s checklist 8 Steps CIOs Must Take to Transform with Artificial Intelligence provides specific recommendations for CIOs to modernize their compute and take their companies to the next level.[i] Source: Forrester Data Global Technographics Data & Analytics Survey, 2017[ii] Source: A commissioned study conducted by Forrester Consulting on behalf of Dell EMC, January 2018.[iii] Source: Forrester Consulting Thought Leadership Checklist Commissioned by Dell EMC, May 2018 Artificial Intelligence is no longer a distant dream of the future. It’s here, and it’s changing the way companies do business.Organizations across all industries have embraced AI to help with everyday operations such as customer service, HR, marketing, sales, R&D and more.A recent survey by Forrester reported that over half of companies worldwide have already implemented AI, and another 20 percent plan to do so within the next year.[i] With good reason. The potential impacts are tremendous – improved processes, increased efficiency, automated workloads, greater ROI and countless other benefits.The question is no longer, “Should we embrace AI?” but rather, “How do we best use it to reach our targeted business outcomes?”AI Initiatives are a Top Priority for IT…For IT departments, the concerns are even more pressing. “How do we prepare for the tsunami of AI projects about to hit us from all areas of the business?”IT leaders know that AI is critical to their firm’s long-term success, and most list it as a top business priority for the upcoming year. CIO.com points out that in Gartner’s 2018 CIO Agenda Report, 47 percent of CIOs who have implemented AI report it as “the most pressing pain point”. Still, despite their knowledge and desire to embrace the technology, IT leaders face many challenges. There is no clear playbook or defined path for implementing AI across an enterprise, which means that many are making it up as they go (and, unsurprisingly, stumbling along the way).…But IT Departments are Often the Last to KnowOne of the most common AI issues is the lack of communication between lines of business and IT departments. When it comes to implementing AI projects, IT is often the last to know. In another recent study, Forrester Consulting found that lines of business “completely bypass IT departments 15 percent to 20 percent of the time on their AI initiatives.”[ii] Not only is this lack of communication frustrating, but it’s inefficient and costly.The good news is that IT leaders are well-suited to lead the AI charge across their organizations. Doing so helps to reduce silos and open lines of communication, increase efficiency, and reduce risk – improvements that directly affect the company’s bottom line. In fact, over half of the companies surveyed expect an ROI up to five times their investment.Although there is no magic, one-size-fits-all playbook, there are some clear steps that IT leaders can take to lead the charge toward transforming with AI.As an IT leader, you should focus on the following to prepare for upcoming AI projects: Modernize Data Management Technology – AI initiatives are based on enormous amounts of data, so it makes sense that that IT will require new tools to effectively manage all that data. If your database, data integration, storage capability and networking aren’t up to the task, now is the time to do something about it.Upgrade Infrastructure Hardware – New AI initiatives require faster response, increased storage, higher bandwidth and low-latency networking. Forrester Consulting showed that 61% of firms are challenged by a lack of servers with purpose-built processors, and 81% pointed to the need for new servers for high-performance computing.[iii] You’ll need highly scalable servers with accelerators to reduce model training times.Evaluate Staffing – AI requires a different set of skills to manage than traditional workloads do, and you may need to hire new staff or invest in training current employees. You’ll need skilled workers that can analyze and interpret the massive amounts of data involved.Deploy Predictive Analytics and Machine Learning Platforms – These platforms enable staff to collaborate and streamline projects across different lines of business. Engineers and data scientists will be able to train, deploy, and manage their models and data pipelines more effectively if they are centrally managed by IT.Implement Text Analytics, Natural Language Processing and Speech Analytics Platforms – These applications can be used in multiple ways across sales, marketing, customer service and R&D.
Digital transformation boils down to one simple common denominator: competitiveness in a future “hyper-digital world,” which Dell Technologies predicts in its latest study, the Digital Transformation Index (DTI). In this futurescape, users have extremely demanding requirements. Economic limitations are a thing of the past, meaning that any company can address any market – but it also means that they have to step into the ring with a constantly growing number of competitors. Innovation plays an even more crucial role in this hyper-digital world, and there are completely new challenges, such as climate change and resource scarcity, that the markets have only had fleeting dealings with – if at all – until now. Companies would do well to factor these futuristic parameters into their calculations.However, these parameters are not actually all that “futuristic.” We have all, at one time or another, looked at the clock after midnight and uttered the words, “Oh, it’s already tomorrow.” For the markets, it’s “already tomorrow” as well. In fact, all of the changes mentioned in the previous paragraph have already begun to take place, be it increased user requirements, stronger competition, or climate change. When we talk about the hyper-digital world, then, we are not talking about some sort of abstract future; it has been the here and now for quite some time! It is also not a sudden development (today versus an undefined “tomorrow”), which would maybe please many procrastinators, but an incremental one – the digital society is taking clearer shape with every passing second. This progression is too slow for many to grasp.The procrastinators and the hesitant should take Albert Einstein’s quote to heart: “I never think of the future – it comes soon enough.” Or, even better, update it: “I never think of the digital future – it has long since arrived. If I don’t act now, I’ll quickly lose my competitiveness.” According to Dell’s DTI, only just over a quarter of those surveyed consider their company to be a leader or implementor in the digital transformation, while the remaining almost 75 percent are taking their time – time that they don’t actually have.Given the high number of digital laggards and (perpetual) evaluators, it is no wonder that those surveyed said that in five years’ time, half of all companies will barely meet the requirements of their customers. Many will also no longer be able to present themselves as credible and reliable partners in their markets as they will have fallen behind from a technological standpoint.At this point, it is worth taking a look at the Global Competitiveness Index 2018 from the World Economic Forum. It lists the most competitive countries, notably the U.S. and Singapore, followed by Germany, Switzerland, and the usual suspects. It would not be too far-fetched to conclude that these industrial nationals are investing the most extensively and at the fastest rate in digitization. After all, they have the most expertise and the largest budgets.Way off the mark. According to the DTI, India, Brazil, and Thailand top the list of most digitization-savvy countries. In developed markets, only 24 percent of companies are among the pioneers in this environment, while in India the number is 45. Who would have thought that emerging economies would be the ones demonstrating how digitization is done?I am well aware that more relaxed data protection and other regulatory provisions form less of a barrier for the economic transformation process in many of these countries when compared to the stringent laws in the EU. In fact, data protection, data security, and legal requirements are some of the biggest hurdles on the path to full digitization. Still, it is worth asking one question: Do India and Thailand top the list of most competitive countries in the hyper-digital world because they systematically carry out numerous actual projects alongside the fact that they work with digitization much more intensively?One could assume that developed markets will fall far behind emerging economies when it comes to digitization – but it probably won’t get to that point. All the same, this scenario can still serve as a cautious wake-up call for one company or another. The momentum of today’s emerging economies should be an example to the global markets.
WNYNewsNow Stock Image.JAMESTOWN — The Jamestown Board of Public Utilities will flush water mains throughout the system starting in early October, weather permitting.Pre-flushing in Falconer will start at 2 p.m. Friday, Oct. 2, in the areas of Aldren, Mapleshade, Ralph and Valmeere. The complete Village of Falconer will be flushed from 8 p.m., Saturday, Oct. 3, overnight into Sunday, Oct. 4, until Falconer is entirely flushed. During Falconer flushing, water may be discolored on the north side of Jamestown as well as in the Village.Flushing of the remainder of the BPU Water Division system will take place from 8:30 a.m. to 4:30 p.m. Monday-Friday, Oct. 5 through 9; and Monday-Wednesday, Oct. 12-14.The exception will be Wednesday, Oct. 7, when flushing will take place from 5:30 a.m. to 5 p.m. to accommodate any downtown and Fairmount Avenue businesses and restaurants. Flushing that day could affect streets directly off Fairmount Avenue and Route 394, even though their streets are not flushed that day. Flushing can discolor water, especially when water line cleaning takes place in the customers’ immediate areas near their scheduled flushing days. Customers may see discolored water at any time during flushing, even on days other than their scheduled flushing days.The BPU’s September customer newsletter contains a two-page color-coded map section showing which areas will be flushed on specific days. The maps also are posted on www.jamestownbpu.com.The BPU website, FACEBOOK and Twitter pages will show daily flushing locations. The BPU recently informed commercial and industrial customers of their flushing dates by automatic calls. Residential customers, whose phone numbers are current on their accounts, can expect to receive such calls two days in advance of their flushing days.Customers with questions about flushing and their flushing dates may call the Flushing Hotline at 661-1688 or Communications at 661-1680.BPU Communications Coordinator Becky Robbins says, “If you receive voicemail when calling, please leave your address, the names of the streets at the end of your block and your phone number. BPU employees will return calls with flushing location dates and with answers to anyquestions.”The main precaution that customers may take during water main flushing is to check for discolored water before doing laundry and to avoid pulling discolored water into their hot water tanks. The BPU also suggests putting aside water for cooking or drinking a day or so ahead of their flushing days because the discolored water is unattractive in appearance. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)